abstract：BACKGROUND:In recent years, schizophrenia has increasingly been recognized as a neurocognitive disorder, which has led to a growing literature on cognitive rehabilitation, and suggested several potential enhancements to cognitive function. For instance, it has been shown that executive functioning deficits as measured ...

journal_title：Schizophrenia research

authors： Ohrmann P,Kugel H,Bauer J,Siegmund A,Kölkebeck K,Suslow T,Wiedl KH,Rothermundt M,Arolt V,Pedersen A

更新日期：2008-12-01 00:00:00

abstract：:We previously reported a schizophrenia associated reduction of neuronal and oligodendrocyte number in the anterior principal thalamic nucleus (APN) in a cohort of severely impaired elderly subjects with schizophrenia (SZ) relative to age matched nonpsychiatric controls (NCs). The present study was undertaken to determ...

journal_title：Schizophrenia research

authors： Byne W,Tatusov A,Yiannoulos G,Vong GS,Marcus S

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Many rating scales have been in use to evaluate various symptomatic domains, and eventually there are too many scales to be selected and widely utilized in busy real-world settings. Relevant, quick, and user-friendly assessment scales are needed to facilitate measurement-based treatment of schizophrenia. MET...

journal_title：Schizophrenia research

authors： Suzuki T,Uchida H,Nomura K,Takeuchi H,Nakajima S,Tanabe A,Yagi G,Watanabe K,Kashima H

更新日期：2008-12-01 00:00:00

abstract：:Individuals diagnosed with schizophrenia spectrum disorders have significant neuropsychological deficits that have been linked to poor functional outcome. As more treatments are developed and implemented for cognitive impairments, it will be important to consider whether people with schizophrenia have insight into the...

journal_title：Schizophrenia research

authors： Medalia A,Thysen J,Freilich B

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Verbal and visual memory deficits are prominent trait markers for schizophrenia, with impairments also observed in first-degree relatives [Snitz, B.E., Macdonald, A.W., 3rd, & Carter, C.S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of put...

journal_title：Schizophrenia research

authors： Skelley SL,Goldberg TE,Egan MF,Weinberger DR,Gold JM

更新日期：2008-10-01 00:00:00

abstract：:The way schizophrenia patients perceive the world is largely mysterious. Understanding and appreciating the visual world begins with the perception of basic visual features, which is altered in this mental disorder. Yet, the roles basic visual features play in functional activities such as appreciation of art are uncl...

journal_title：Schizophrenia research

authors： Chen Y,Norton D,McBain R

更新日期：2008-10-01 00:00:00

abstract：:Language disturbance is one of the main diagnostic features in schizophrenia and abnormalities of brain language areas have been consistently found in schizophrenic patients. The main aim of this study was to describe the impairment of micro and macrolinguistic abilities in a group of twenty-nine schizophrenic patient...

journal_title：Schizophrenia research

authors： Marini A,Spoletini I,Rubino IA,Ciuffa M,Bria P,Martinotti G,Banfi G,Boccascino R,Strom P,Siracusano A,Caltagirone C,Spalletta G

更新日期：2008-10-01 00:00:00

abstract：:Glutamate cycling is critically important for neurotransmission, and may be altered in schizophrenia. The excitatory amino acid transporters (EAATs) facilitate the reuptake of glutamate from the synaptic cleft and have a key role in glutamate cycling. We hypothesized that expression of the EAATs and the EAAT regulatin...

journal_title：Schizophrenia research

authors： Bauer D,Gupta D,Harotunian V,Meador-Woodruff JH,McCullumsmith RE

更新日期：2008-09-01 00:00:00

abstract：:The longitudinal course of primary cognitive dysfunction seen in schizophrenia has yet to be fully clarified. Whereas some studies in chronic patients have revealed a progressive decline in cognitive abilities, those studies with first-episode patients have indicated that initial cognitive deficits might remain stable...

journal_title：Schizophrenia research

authors： Rodríguez-Sánchez JM,Pérez-Iglesias R,González-Blanch C,Pelayo-Terán JM,Mata I,Martínez O,Sánchez-Cubillo I,Vázquez-Barquero JL,Crespo-Facorro B

更新日期：2008-09-01 00:00:00

abstract：:Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...

journal_title：Schizophrenia research

authors： Fatemi SH,Folsom TD,Reutiman TJ,Pandian T,Braun NN,Haug K

更新日期：2008-09-01 00:00:00

abstract：:Recent studies suggest that both executive dysfunction and personality traits combine with symptoms to affect the social outcome of persons with schizophrenia. This study was designed to investigate how personality traits influence executive function in schizophrenia. Forty-four patients with schizophrenia and twenty-...

journal_title：Schizophrenia research

authors： Guillem F,Pampoulova T,Rinaldi M,Stip E

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. METHODS:Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic re...

journal_title：Schizophrenia research

authors： Bramon E,Dempster E,Frangou S,Shaikh M,Walshe M,Filbey FM,McDonald C,Sham P,Collier DA,Murray R

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...

journal_title：Schizophrenia research

authors： Mulholland C,Boyle C,Shannon C,Huda U,Clarke L,Meenagh C,Dempster M

更新日期：2008-07-01 00:00:00

abstract：:Dysfunction in the neuronal nicotinic acetylcholine receptor (nAChR) system has been implicated in the pathophysiology of schizophrenia, and it has been postulated that treatments that increase nAChR activity may improve symptoms of the disorder. We investigated the effects of the acetylcholinesterase inhibitor and al...

journal_title：Schizophrenia research

authors： Dyer MA,Freudenreich O,Culhane MA,Pachas GN,Deckersbach T,Murphy E,Goff DC,Evins AE

更新日期：2008-07-01 00:00:00

abstract：:Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...

journal_title：Schizophrenia research

authors： Strauss GP,Allen DN,Duke LA,Ross SA,Schwartz J

更新日期：2008-07-01 00:00:00

abstract：:Schizophrenia is associated with significant brain abnormalities, including changes in brain metabolites as measured by proton magnetic resonance spectroscopy (MRS). What remains unclear is the extent to which these changes are a consequence of the emergence of psychotic disorders or the result of treatment with antip...

journal_title：Schizophrenia research

authors： Wood SJ,Berger GE,Wellard RM,Proffitt T,McConchie M,Velakoulis D,McGorry PD,Pantelis C

更新日期：2008-07-01 00:00:00

abstract：:Abnormality of P300 waveforms of event-related potentials (ERPs) has been suggested to represent an aspect of the pathophysiology of schizophrenia. Previous work points to the contribution of altered neural function in discrete brain regions in the left hemisphere to psychotic symptoms and cognitive deficits of schizo...

journal_title：Schizophrenia research

authors： Higuchi Y,Sumiyoshi T,Kawasaki Y,Matsui M,Arai H,Kurachi M

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE(S):To characterize the longitudinal patterns of antipsychotic treatment and to investigate the relationship between antipsychotic treatment patterns and acute hospitalizations among adults with schizophrenia. We hypothesized that continuous antipsychotic treatment would be associated with fewer hospitalizatio...

journal_title：Schizophrenia research

authors： dosReis S,Johnson E,Steinwachs D,Rohde C,Skinner EA,Fahey M,Lehman AF

更新日期：2008-04-01 00:00:00

abstract：:Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituen...

journal_title：Schizophrenia research

authors： Seal ML,Yücel M,Fornito A,Wood SJ,Harrison BJ,Walterfang M,Pell GS,Pantelis C

更新日期：2008-04-01 00:00:00

abstract：:Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the a...

journal_title：Schizophrenia research

authors： Ikeda M,Takahashi N,Saito S,Aleksic B,Watanabe Y,Nunokawa A,Yamanouchi Y,Kitajima T,Kinoshita Y,Kishi T,Kawashima K,Hashimoto R,Ujike H,Inada T,Someya T,Takeda M,Ozaki N,Iwata N

更新日期：2008-04-01 00:00:00

abstract：:Although a substance use disorder (SUD) is traditionally associated with psycho-bio-social impairments, recent investigations among persons with schizophrenia (Sz) generated divergent results. Certain persons with Sz+SUD might in fact present better social and cognitive functioning than persons with Sz without SUD. Th...

journal_title：Schizophrenia research

authors： Potvin S,Joyal CC,Pelletier J,Stip E

更新日期：2008-03-01 00:00:00

abstract：:Deficits in learning and memory are among the most robust correlates of schizophrenia. It has been hypothesized that these deficits are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval. The Remember-Know (R-K) paradigm was administered to 35 patien...

journal_title：Schizophrenia research

authors： van Erp TG,Lesh TA,Knowlton BJ,Bearden CE,Hardt M,Karlsgodt KH,Shirinyan D,Rao V,Green MF,Subotnik KL,Nuechterlein K,Cannon TD

更新日期：2008-03-01 00:00:00

abstract：:Heterozygous reeler mouse has been used as an animal model for schizophrenia based on several neuropathological and behavioral abnormalities homologous to schizophrenia. Since some of these abnormalities are primarily associated with altered BDNF signaling we investigated BDNF signaling in the frontal cortex of reeler...

journal_title：Schizophrenia research

authors： Pillai A,Mahadik SP

更新日期：2008-03-01 00:00:00

abstract：:Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...

journal_title：Schizophrenia research

authors： Patterson TL,Leeuwenkamp OR

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The long-term evolution of neuroleptic-induced extrapyramidal syndromes (EPS) of Parkinsonism, akathisia and tardive dyskinesia (TD) is still a controversial issue worth exploring. METHOD:A total of 200 inpatients on regular typical neuroleptics (NL) and/or clozapine were assessed in 1995 with regard to the...

journal_title：Schizophrenia research

authors： Modestin J,Wehrli MV,Stephan PL,Agarwalla P

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. METHODS:Fifty three papers met criteria for inclusion into the review and 15 were included in ...

journal_title：Schizophrenia research

authors： Boutros NN,Arfken C,Galderisi S,Warrick J,Pratt G,Iacono W

更新日期：2008-02-01 00:00:00

abstract：:Recent meta-analytic evidence suggests that clinical neuropsychological methods are not likely to uncover circumscribed cognitive impairments in the deficit syndrome of schizophrenia. To overcome this issue, we adapted a cognitive neuroscience perspective and used a new "chaining" habit learning task. Participants wer...

journal_title：Schizophrenia research

authors： Polgár P,Farkas M,Nagy O,Kelemen O,Réthelyi J,Bitter I,Myers CE,Gluck MA,Kéri S

更新日期：2008-02-01 00:00:00

abstract：:In previous studies of self-monitoring in schizophrenia, patients have exhibited reductions in the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) elicited most prominently immediately following the execution of incorrect responses. In the current study, we exami...

journal_title：Schizophrenia research

authors： Morris SE,Heerey EA,Gold JM,Holroyd CB

更新日期：2008-02-01 00:00:00

abstract：:Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...

journal_title：Schizophrenia research

authors： Ragland JD,Moelter ST,Bhati MT,Valdez JN,Kohler CG,Siegel SJ,Gur RC,Gur RE

更新日期：2008-02-01 00:00:00

abstract：:Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) administration of influenza virus. We hypothesized that l...

journal_title：Schizophrenia research

authors： Fatemi SH,Reutiman TJ,Folsom TD,Huang H,Oishi K,Mori S,Smee DF,Pearce DA,Winter C,Sohr R,Juckel G

更新日期：2008-02-01 00:00:00

abstract：:Glutamate was quantified by proton magnetic resonance spectroscopy ((1)H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT). Subjects were free of psychopathology but the HR group sh...

journal_title：Schizophrenia research

authors： Purdon SE,Valiakalayil A,Hanstock CC,Seres P,Tibbo P

更新日期：2008-02-01 00:00:00

abstract：:Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls ...

journal_title：Schizophrenia research

authors： Kale A,Joshi S,Naphade N,Sapkale S,Raju MS,Pillai A,Nasrallah H,Mahadik SP

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually d...

journal_title：Schizophrenia research

authors： Narvaez JM,Twamley EW,McKibbin CL,Heaton RK,Patterson TL

更新日期：2008-01-01 00:00:00

abstract：:Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who ...

journal_title：Schizophrenia research

authors： Turkington D,Sensky T,Scott J,Barnes TR,Nur U,Siddle R,Hammond K,Samarasekara N,Kingdon D

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To investigate gender differences in the onset and other clinical features of Han Chinese inpatients with schizophrenia. METHODS:Five-hundred-and-forty-two Han Chinese inpatients with DSM-IV schizophrenia were assessed with the Positive and Negative Symptoms Scale (PANSS), the Brief Psychiatric Rating Scale ...

journal_title：Schizophrenia research

authors： Tang YL,Gillespie CF,Epstein MP,Mao PX,Jiang F,Chen Q,Cai ZJ,Mitchell PB

更新日期：2007-12-01 00:00:00

abstract：:Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schi...

journal_title：Schizophrenia research

authors： Esterberg ML,Jones EM,Compton MT,Walker EF

更新日期：2007-12-01 00:00:00

abstract：:The guarantee of perceptual coherence for events through everyday life situations depends upon the capacity to correctly integrate series of multi-sensory experiences. Patients with schizophrenia have been shown to reveal a deficit in integrating, i.e., "binding", perceptual information together. However, results in t...

journal_title：Schizophrenia research

authors： Foucher JR,Lacambre M,Pham BT,Giersch A,Elliott MA

更新日期：2007-12-01 00:00:00

abstract：:The number of psychiatric beds has declined considerably in many countries over the past decades. Long-term studies on the impact of these health care changes for the severely mentally ill, however, are still scarce. This epidemiological study investigates the use of inpatient psychiatric services by people with schiz...

journal_title：Schizophrenia research

authors： Lay B,Nordt C,Rössler W

更新日期：2007-12-01 00:00:00

abstract：:The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology mediating these effects; however,...

journal_title：Schizophrenia research

authors： O'Connor JA,Hemby SE

更新日期：2007-12-01 00:00:00

abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...

journal_title：Schizophrenia research

authors： Lasser RA,Nasrallah H,Helldin L,Peuskens J,Kane J,Docherty J,Tronco AT

更新日期：2007-11-01 00:00:00